VYRE Business News Global (VBNGtv) has unveiled its annual “Top 50 Small-Cap Market Movers for 2025,” spotlighting standout performers that captured investor attention over the past year. As a digital business news network focused on small and micro-cap innovation, VBNGtv continues to champion emerging companies and forward-thinking leaders through original reporting, in-depth analysis and research, and exclusive interviews that bring the small-cap sector into sharper focus.
With 2025 marking another year of remarkable growth and volatility in the small-cap landscape, VBNGtv analyzed 1,495 companies with market capitalizations between $300 million and $2 billion. The final list celebrates the top 50 stocks that delivered the strongest share price gains from December 31, 2024, to December 31, 2025. Companies trading fewer than six months were excluded, while three firms achieved a milestone, graduating from small- to mid-cap status as their valuations soared past $2 billion.
Later this year, VBNGtv plans to expand its coverage with live business-day programming, delivering timely market insights directly to investors and executives navigating the fast-moving world of small-cap equities.
To see how these companies performed in the first half of the year, visit the Top 50 Small-Cap Market Movers for the First 7 Months of 2025.
1. The Oncology Institute, Inc.
Ticker: TOI
Stock Price as of Dec 31, 2024: $0.31
Stock Price as of Dec 31, 2025: $3.56
2025 % Increase/ Decrease: 1052.10%
The Oncology Institute, Inc. delivers highly specialized, value-based cancer care through community-based clinics, serving over 1.8 million patients with advanced, evidence-based treatments and personalized care.
2. Hycroft Mining Holding Corporation
Ticker: HYMC
Stock Price as of Dec 31, 2024: $2.21
Stock Price as of Dec 31, 2025: $23.77
2025 % Increase/ Decrease: 975.57%
Hycroft Mining Holding Corporation is a precious metals development company that owns and operates the Hycroft Mine in Northern Nevada, focusing on gold and silver exploration, development, and production from one of the world’s largest deposits.
3. Zepp Health Corporation
Ticker: ZEPP
Stock Price as of Dec 31, 2024: $2.60
Stock Price as of Dec 31, 2025: $26.94
2025 % Increase/ Decrease: 936.15%
Zepp Health Corporation is a health technology company that designs, develops, and sells smart wearable devices like Amazfit smartwatches and fitness trackers, alongside health management platforms and apps.
4. Almonty Industries Inc.
Ticker: ALM
Stock Price as of Dec 31, 2024: $0.94
Stock Price as of Dec 31, 2025: $8.81
2025 % Increase/ Decrease: 840.13%
Almonty Industries Inc. is a mining company that specializes in tungsten production, operating mines in Canada, Spain, and Portugal, with a focus on global tungsten supply through its flagship Sangdong project in South Korea.
5. NovaBay Pharmaceuticals, Inc.
Ticker: NBY
Stock Price as of Dec 31, 2024: $0.601
Stock Price as of Dec 31, 2025: $5.64
2025 % Increase/ Decrease: 838.44%
NovaBay Pharmaceuticals, Inc. is a biopharmaceutical company that develops and commercializes non-antibiotic anti-infective products based on its proprietary NeutroPhase and Avenova platforms for eye care, wound care, and infection prevention.
6. Relmada Therapeutics, Inc.
Ticker: RLMD
Stock Price as of Dec 31, 2024: $0.52
Stock Price as of Dec 31, 2025: $4.83
2025 % Increase/ Decrease: 828.85%
Relmada Therapeutics, Inc. is a clinical-stage biotechnology company that develops novel treatments for central nervous system disorders, primarily focusing on its NMDA receptor antagonist relmadalin for major depressive disorder.
7. Palvella Therapeutics, Inc.
Ticker: PVLA
Stock Price as of Dec 31, 2024: $12.00
Stock Price as of Dec 31, 2025: $104.67
2025 % Increase/ Decrease: 772.25%
Palvella Therapeutics, Inc. is a clinical-stage rare disease company that develops therapies for genetic skin diseases, advancing its lead candidate QTORIN for pachyonychia congenita and other keratin disorders.
8. Nanobiotix S.A.
Ticker: NBTX
Stock Price as of Dec 31, 2024: $2.87
Stock Price as of Dec 31, 2025: $23.12
2025 % Increase/ Decrease: 705.58%
Nanobiotix S.A. is a clinical-stage nanomedicine company that develops radioenhancers like NBTXR3 to improve cancer treatments by amplifying radiotherapy effects in tumors.
9. Anbio Biotechnology
Ticker: NNNN
Stock Price as of Dec 31, 2024: $5.26
Stock Price as of Dec 31, 2025: $30.07
2025 % Increase/ Decrease: 498.22%
Anbio Biotechnology is a biotechnology company that manufactures rapid diagnostic tests and in-vitro diagnostic reagents for infectious diseases, cardiac markers, and other health conditions. The company supplies point-of-care testing kits globally, focusing on affordable, user-friendly diagnostics for healthcare providers.
10. Diginex Limited
Ticker: DGNX
Stock Price as of Dec 31, 2024: $0.5325
Stock Price as of Dec 31, 2025: $4.17
2025 % Increase/ Decrease: 683.10%
Diginex Limited is a digital assets company that provides ESG-focused blockchain solutions, including cryptocurrency trading platforms and sustainable digital finance services.
11. AXT, Inc.
Ticker: AXTI
Stock Price as of Dec 31, 2024: $2.17
Stock Price as of Dec 31, 2025: $16.35
2025 % Increase/ Decrease: 653.46%
AXT, Inc. is a semiconductor materials company that manufactures high-performance indium phosphide wafers and related substrates for wireless communications, data centers, and silicon photonics applications.
12. Avino Silver & Gold Mines Ltd.
Ticker: ASM
Stock Price as of Dec 31, 2024: $0.881
Stock Price as of Dec 31, 2025: $6.21
2025 % Increase/ Decrease: 604.88%
Avino Silver & Gold Mines Ltd. is a mining company that explores, develops, and produces silver, gold, and copper primarily from its Avino Mine near Durango, Mexico. The company processes ore into concentrates sold to smelters and traders, focusing on profitable growth through organic expansion and strategic acquisitions like the La Preciosa project.
13. Newegg Commerce, Inc.
Ticker: NEGG
Stock Price as of Dec 31, 2024: $7.928
Stock Price as of Dec 31, 2025: $50.76
2025 % Increase/ Decrease: 540.26%
Newegg Commerce, Inc. is an e-commerce company that operates an online marketplace specializing in electronics, computers, gaming products, and related accessories. It serves consumers and businesses through its platform, offering direct sales, third-party seller listings, and services like logistics and advertising.
14. DBV Technologies S.A.
Ticker: DBVT
Stock Price as of Dec 31, 2024: $3.09
Stock Price as of Dec 31, 2025: $19.17
2025 % Increase/ Decrease: 520.39%
DBV Technologies S.A. is a biopharmaceutical company that develops therapies for food allergies, notably using its Viaskin epicutaneous immunotherapy platform. The firm focuses on treatments like Viaskin Peanut for peanut allergy desensitization in children and advances clinical trials for other allergens.
15. Aimei Health Technology Co., Ltd
Ticker: AFJK
Stock Price as of Dec 31, 2024: $10.70
Stock Price as of Dec 31, 2025: $64.01
2025 % Increase/ Decrease: 498.22%
Aimei Health Technology Co., Ltd is a medical technology company that develops innovative health devices, particularly in biotechnology and diagnostics for disease detection and management. It emphasizes point-of-care testing solutions and health monitoring technologies tailored for clinical and consumer use.
16. Invivyd, Inc.
Ticker: IVVD
Stock Price as of Dec 31, 2024: $0.4431
Stock Price as of Dec 31, 2025: $2.47
2025 % Increase/ Decrease: 457.44%
Invivyd, Inc. is a biopharmaceutical company that develops monoclonal antibodies for infectious diseases, particularly respiratory viruses like COVID-19. It commercializes products like PEMGARDA for pre-exposure prophylaxis against COVID-19 in high-risk individuals.
17. The metals company Inc.
Ticker: TMC
Stock Price as of Dec 31, 2024: $1.12
Stock Price as of Dec 31, 2025: $6.17
2025 % Increase/ Decrease: 450.89%
TMC the metals company Inc. is an exploration and development company that focuses on deep-sea polymetallic nodule collection for battery metals like nickel, cobalt, copper, and manganese. It targets sustainable mining from the Clarion-Clipperton Zone in the Pacific Ocean to supply the electric vehicle industry.
18. Americas Gold and Silver Corporation
Ticker: USAS
Stock Price as of Dec 31, 2024: $0.9398
Stock Price as of Dec 31, 2025: $5.11
2025 % Increase/ Decrease: 443.73%
Americas Gold and Silver Corporation is a mining company that produces silver and gold from underground mines in the U.S. and Mexico, including the Cosalá Operations and Galena Complex. It processes ore into concentrates and emphasizes low-cost production with exploration upside.
19. Nutex Health Inc.
Ticker: NUTX
Stock Price as of Dec 31, 2024: $31.69
Stock Price as of Dec 31, 2025: $164.62
2025 % Increase/ Decrease: 419.47%
Nutex Health Inc. is a healthcare management company that operates micro-hospitals, telemedicine platforms, and physician practices across the U.S. It focuses on efficient, physician-led care delivery through its “hospital within a hospital” model and virtual health services.
20. Inhibrx Biosciences, Inc.
Ticker: INBX
Stock Price as of Dec 31, 2024: $15.40
Stock Price as of Dec 31, 2025: $79.00
2025 % Increase/ Decrease: 412.99%
Inhibrx Biosciences, Inc. is a clinical-stage biopharmaceutical company that develops protein therapeutics using its proprietary protein scaffolding platform for oncology and rare diseases. It advances pipeline candidates like INBRX-109 for cancer treatments through preclinical and clinical programs.
21. Resolute Holdings Management, Inc.
Ticker: RHLD
Stock Price as of Dec 31, 2024: $41.61
Stock Price as of Dec 31, 2025: $206.43
2025 % Increase/ Decrease: 396.11%
Resolute Holdings Management, Inc. is a holding company that provides asset management services, including oversight of capital allocation strategy, operational practices, and merger and acquisition activities through its subsidiaries, primarily managing CompoSecure Holdings.
22. Village Farms International, Inc.
Ticker: VFF
Stock Price as of Dec 31, 2024: $0.771
Stock Price as of Dec 31, 2025: $3.65
2025 % Increase/ Decrease: 373.41%
Village Farms International, Inc. is an agricultural company that produces and sells cannabis products, fresh produce, and plant-based foods through its operations in Canada and the U.S. It operates licensed cannabis facilities and vertical farms, distributing to recreational, medical, and food markets.
23. NovaBridge Biosciences
Ticker: NBP
Stock Price as of Dec 31, 2024: $0.85
Stock Price as of Dec 31, 2025: $3.98
2025 % Increase/ Decrease: 368.24%
NovaBridge Biosciences is a biotechnology company that engineers protein-based therapeutics using computational design platforms for targeted therapies in oncology and immunology. It develops novel biologics to bridge immune cells and disease targets for enhanced treatment efficacy.
24. Integra Resources Corp.
Ticker: ITRG
Stock Price as of Dec 31, 2024: $0.8699
Stock Price as of Dec 31, 2025: $4.01
2025 % Increase/ Decrease: 360.97%
Integra Resources Corp. is a precious metals mining company that explores, develops, and produces gold and silver deposits primarily in the Great Basin region of the Western United States. Its key assets include the operating Florida Canyon Mine in Nevada and development projects like DeLamar in Idaho.
25. ThredUp Inc.
Ticker: TDUP
Stock Price as of Dec 31, 2024: $1.39
Stock Price as of Dec 31, 2025: $6.39
2025 % Increase/ Decrease: 359.71%
ThredUp Inc. is an online resale platform company that operates a consumer-to-consumer marketplace for secondhand apparel, footwear, and accessories. It facilitates clothing swaps, sales, and sustainability-focused fashion resale through its proprietary technology and logistics network.
26. Zenas BioPharma, Inc.
Ticker: ZBIO
Stock Price as of Dec 31, 2024: $7.98
Stock Price as of Dec 31, 2025: $36.31
2025 % Increase/ Decrease: 343.35%
Zenas BioPharma, Inc. is a clinical-stage biopharmaceutical company that develops immunology-based therapies for autoimmune and rare diseases. It advances a pipeline of innovative treatments, including obexelimab for conditions like IgG4-related disease, targeting patients in the US, China, and globally.
27. Anywhere Real Estate Inc.
Ticker: HOUS
Stock Price as of Dec 31, 2024: $3.30
Stock Price as of Dec 31, 2025: $14.16
2025 % Increase/ Decrease: 329.09%
Anywhere Real Estate Inc. is a real estate franchisor and brokerage company that owns brands like Coldwell Banker and Sotheby’s International Realty. It provides residential and commercial real estate services, including listings, mortgages, and relocation support across North America.
28. Olema Pharmaceuticals, Inc.
Ticker: OLMA
Stock Price as of Dec 31, 2024: $5.83
Stock Price as of Dec 31, 2025: $25.00
2025 % Increase/ Decrease: 328.82%
Olema Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company that focuses on developing precision medicines for women’s cancers. Its lead candidate, palazoparib, targets hormone receptor-positive breast cancer through selective estrogen receptor degradation.
29. Sify Technologies Limited
Ticker: SIFY
Stock Price as of Dec 31, 2024: $2.86
Stock Price as of Dec 31, 2025: $12.19
2025 % Increase/ Decrease: 326.22%
Sify Technologies Limited is a digital services and infrastructure company that offers IT consulting, cloud computing, data center hosting, and network managed services. It serves enterprises in India with solutions for digital transformation, cybersecurity, and e-commerce platforms.
30. Alto Neuroscience, Inc.
Ticker: ANRO
Stock Price as of Dec 31, 2024: $4.23
Stock Price as of Dec 31, 2025: $17.80
2025 % Increase/ Decrease: 320.80%
Alto Neuroscience, Inc. is a precision psychiatry company that develops personalized treatments for mental health disorders like depression and PTSD. It uses brain biomarkers and AI-driven diagnostics to match patients with optimal therapies.
31. SuperX AI Technology Limited
Ticker: SUPX
Stock Price as of Dec 31, 2024: $3.75
Stock Price as of Dec 31, 2025: $15.68
2025 % Increase/ Decrease: 318.13%
SuperX AI Technology Limited is an artificial intelligence company that builds advanced AI models and platforms for enterprise applications. It specializes in scalable AI infrastructure, machine learning optimization, and sector-specific solutions like healthcare and finance.
32. CytomX Therapeutics, Inc.
Ticker: CTMX
Stock Price as of Dec 31, 2024: $1.03
Stock Price as of Dec 31, 2025: $4.26
2025 % Increase/ Decrease: 313.59%
CytomX Therapeutics, Inc. is a clinical-stage oncology company that engineers conditionally activated biologics for cancer immunotherapy. Its Probody platform masks therapeutic antibodies until they reach the tumor microenvironment, reducing systemic toxicity.
33. Ventyx Biosciences, Inc.
Ticker: VTYX
Stock Price as of Dec 31, 2024: $2.19
Stock Price as of Dec 31, 2025: $9.03
2025 % Increase/ Decrease: 312.33%
Ventyx Biosciences, Inc. is a clinical-stage biopharmaceutical company that discovers small molecule inhibitors for inflammatory diseases. It targets kinases like TYK2 for conditions including psoriasis, Crohn’s disease, and alopecia areata.
34. International Tower Hill Mines Ltd.
Ticker: THM
Stock Price as of Dec 31, 2024: $0.4554
Stock Price as of Dec 31, 2025: $1.86
2025 % Increase/ Decrease: 308.43%
International Tower Hill Mines Ltd. is a mineral exploration company that holds advanced-stage gold projects in North America. Its flagship Livengood gold project in Alaska features significant resources under development evaluation.
35. Idaho Strategic Resources, Inc.
Ticker: IDR
Stock Price as of Dec 31, 2024: $10.19
Stock Price as of Dec 31, 2025: $40.30
2025 % Increase/ Decrease: 295.49%
Idaho Strategic Resources, Inc. is a gold mining and exploration company that operates the Golden Chest Mine in Idaho. It focuses on high-grade underground gold production and regional exploration opportunities.
36. Babcock & Wilcox Enterprises, Inc.
Ticker: BW
Stock Price as of Dec 31, 2024: $1.64
Stock Price as of Dec 31, 2025: $6.34
2025 % Increase/ Decrease: 286.59%
Babcock & Wilcox Enterprises, Inc. is an energy technology company that provides clean energy solutions, including steam generation systems, environmental controls, and advanced thermal technologies. It supports power generation, industrial, and renewable sectors with emission reduction tech.
37. Etoiles Capital Group Co., Ltd
Ticker: EFTY
Stock Price as of Dec 31, 2024: $4.00
Stock Price as of Dec 31, 2025: $15.02
2025 % Increase/ Decrease: 275.50%
Etoiles Capital Group Co., Ltd is an investor relations services company that provides integrated solutions including public relations, advertising, investor relations management, due diligence, and website design across Hong Kong, China, and the United States.
38. Precigen, Inc.
Ticker: PGEN
Stock Price as of Dec 31, 2024: $1.12
Stock Price as of Dec 31, 2025: $4.18
2025 % Increase/ Decrease: 273.21%
Precigen, Inc. is a discovery and clinical-stage biopharmaceutical company that develops gene and cell therapies using precision technologies like AdenoVerse gene delivery and UltraCAR-T platforms to target immuno-oncology, autoimmune disorders, and infectious diseases.
39. China Yuchai International Limited
Ticker: CYD
Stock Price as of Dec 31, 2024: $9.53
Stock Price as of Dec 31, 2025: $35.50
2025 % Increase/ Decrease: 272.51%
China Yuchai International Limited is a holding company engaged in the manufacturing, distribution, and sale of diesel engines for commercial vehicles, construction machinery, and agricultural equipment through its subsidiaries in China.
40. Trilogy Metals Inc.
Ticker: TMQ
Stock Price as of Dec 31, 2024: $1.16
Stock Price as of Dec 31, 2025: $4.31
2025 % Increase/ Decrease: 271.55%
Trilogy Metals Inc. is a mineral exploration and development company advancing high-grade copper, zinc, and gold projects in Alaska’s Ambler Mining District. Its flagship Arctic Project is one of the most promising volcanogenic massive sulfide deposits in North America.
41. Compass Therapeutics, Inc.
Ticker: CMPX
Stock Price as of Dec 31, 2024: $1.45
Stock Price as of Dec 31, 2025: $5.37
2025 % Increase/ Decrease: 270.35%
Compass Therapeutics, Inc. is a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics, including bispecific antibodies, that target immune-mediated pathways.
42. AnaptysBio, Inc.
Ticker: ANAB
Stock Price as of Dec 31, 2024: $13.24
Stock Price as of Dec 31, 2025: $48.48
2025 % Increase/ Decrease: 266.16%
AnaptysBio, Inc. is a clinical-stage biotechnology company specializing in the discovery and development of novel antibody therapeutics for autoimmune and inflammatory diseases through its proprietary somatic hypermutation platform.
43. Better Home & Finance Holding Company
Ticker: BETR
Stock Price as of Dec 31, 2024: $8.92
Stock Price as of Dec 31, 2025: $32.58
2025 % Increase/ Decrease: 265.25%
Better Home & Finance Holding Company, operating as Better.com, is a digitally native homeownership platform headquartered in New York City that delivers mortgage origination, title insurance, homeowners insurance, and real estate services primarily to customers in the United States and United Kingdom.
44. Owlet, Inc.
Ticker: OWLT
Stock Price as of Dec 31, 2024: $4.45
Stock Price as of Dec 31, 2025: $16.19
2025 % Increase/ Decrease: 263.82%
Owlet, Inc. is a pioneering wearable technology company specializing in smart baby monitoring solutions that help parents track their infants’ vital signs in real time. Its flagship product, the Smart Sock, combines advanced sensors and app connectivity to provide continuous health insights.
45. SELLAS Life Sciences Group, Inc.
Ticker: SLS
Stock Price as of Dec 31, 2024: $1.87
Stock Price as of Dec 31, 2025: $3.77
2025 % Increase/ Decrease: 262.50%
SELLAS Life Sciences Group, Inc. is a late-stage clinical biopharmaceutical company that develops novel cancer immunotherapies, including its lead candidate galinpepimut-S (GPS), a peptide-based immunotherapy targeting Wilms Tumor 1 (WT1) protein expressed in various leukemias and solid tumors.
46. DRDGOLD Limited
Ticker: DRD
Stock Price as of Dec 31, 2024: $8.63
Stock Price as of Dec 31, 2025: $31.01
2025 % Increase/ Decrease: 259.33%
DRDGOLD Limited is a gold mining company that operates surface gold retreatment operations, recovering gold from tailings material at its Far West Rand Gold Hub and Ergo operations in South Africa.
47. nLIGHT, Inc.
Ticker: LASR
Stock Price as of Dec 31, 2024: $10.49
Stock Price as of Dec 31, 2025: $37.51
2025 % Increase/ Decrease: 257.58%
nLIGHT, Inc. is a laser technology company that designs and manufactures high-power semiconductors, fiber lasers, and laser systems for industrial applications like materials processing, welding, and cutting, as well as defense uses including directed energy and sensing.
48. Xunlei Limited
Ticker: XNET
Stock Price as of Dec 31, 2024: $1.99
Stock Price as of Dec 31, 2025: $7.09
2025 % Increase/ Decrease: 256.28%
Xunlei Limited is an internet technology company that provides cloud acceleration, shared computing, digital entertainment, and blockchain-based services primarily in China.
49. Collective Mining Ltd.
Ticker: CNL
Stock Price as of Dec 31, 2024: $4.16
Stock Price as of Dec 31, 2025: $14.59
2025 % Increase/ Decrease: 250.72%
Collective Mining Ltd. is a mineral exploration company that focuses on discovering and advancing copper-gold projects in Colombia, primarily through its flagship Guayabales project which hosts multiple high-grade porphyry systems.
50. Gossamer Bio, Inc.
Ticker: GOSS
Stock Price as of Dec 31, 2024: $0.9046
Stock Price as of Dec 31, 2025: $3.10
2025 % Increase/ Decrease: 242.69%
Gossamer Bio, Inc. is a clinical-stage biopharmaceutical company that develops innovative small-molecule therapies for chronic inflammatory diseases, with a primary focus on pulmonary arterial hypertension (PAH) and other cardiopulmonary conditions.
*Disclosure: VYRE Business News Global (VBNGtv) and its affiliates do not hold any financial interest in the companies mentioned in this article, including through equity ownership, options, or any other forms of securities or derivatives. This article was independently prepared and reflects the editorial opinions of VBNGtv. As of the publication date, VBNGtv maintains no commercial or financial relationships with any company referenced herein.
